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The Human Connection: Reference Our Research with Results

The Human Connection: Reference Our Research with Results

Find the research studies cited in the cover story of The Oath's Spring 2024 issue here.

‘Bench to bedside’ research takes a unique form at the NC State College of Veterinary Medicine, where advancements bridging veterinary research and human health care can span ‘barn to bedside’ or ‘farm to table.’

Here, you can find all the translational and comparative research studies referenced in the cover story of our Spring 2024 issue of The Oath and dive deeper into our faculty and student researchers’ strides to improve animal and human health. Studies appear in the order they are mentioned in the main article.

Introduction

  • “A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease.” Cecilia R. Schaaf, Kathryn M. Polkoff, Amber Carter, Amy S. Stewart, Breanna Sheahan, John Freund, Joshua Ginzel, Joshua C. Snyder, Jatin Roper, Jorge A. Piedrahita and Liara M. Gonzalez. The FASEB Journal, vol. 37, issue 6. May 2023. https://doi.org/10.1096/fj.202300223R
    • Related: “NC State Gastroenterologist Awarded $3.5 Million NIH Grant to Improve Small Intestine Transplant Process.” NC State University Veterinary Medicine News, Feb. 15, 2024. https://news.cvm.ncsu.edu/gonzalez-nih-grant/

Helping Whole-Body Health

Cancer

Infectious Disease

  • “A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model.” Jessica M. Gilbertie, Thomas P. Schaer, Julie B. Engiles, Gabriela S. Seiler, Bennett L. Deddens, Alicia G. Schubert, Megan E. Jacob, Darko Stefanovski, Gordon Ruthel, Noreen J. Hickok, Devorah M. Stowe, Alexa Frink and Lauren V. Schnabel. Frontiers in Cellular and Infection Microbiology, vol. 12. May 30, 2022. https://doi.org/10.3389/fcimb.2022.895022
  • “Effect of BIO-PLY(TM), a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages.” Alba Frias-De-Diego, Jessica M. Gilbertie, Frank Scholle, Sarah Dejarnette and Elisa Crisci. Viruses, vol. 14, issue 12. Nov. 28, 2022. https://doi.org/10.3390/v14122666
  • “Geographic disparities and predictors of COVID-19 vaccination in Missouri: a retrospective ecological study.” Alexanderia Lacy, Md Marufuzzaman Khan, Nirmalendu Deb Nath, Praachi Das, Morganne Igoe, Suzanne Lenhart, Alun L. Lloyd, Cristina Lanzas and Agricola Odoi. Frontiers in Public Health, vol. 12. March 10, 2024. https://doi.org/10.3389/fpubh.2024.1329382
  • “Viability and Desiccation Resistance of Bartonella henselae in Biological and Non-Biological Fluids: Evidence for Pathogen Environmental Stability.” Janice C. Bush, Ricardo G. Maggi and Edward B. Breitschwerdt. Pathogens, vol. 12, issue 7. July 18, 2023. https://doi.org/10.3390/pathogens12070950

Food Safety

  • “Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.” Mabel Kamweli Aworh, Siddhartha Thakur, Catherine Gensler, Erin Harrell, Lyndy Harden, Paula J. Fedorka-Cray and Megan Jacob. PLOS ONE, vol. 19, issue 1. Jan. 5, 2024. https://doi.org/10.1371/journal.pone.0294099
  • “Serovar-level identification of bacterial foodborne pathogens from full-length 16S rRNA gene sequencing.” Dmitry Grinevich, Lyndy Harden, Siddhartha Thakur and Benjamin Callahan. mSystems, vol. 9. Feb. 6, 2024. https://doi.org/10.1128/msystems.00757-23

Boosting Body Systems

Nervous

  • “Relationship between hearing, cognitive function, and quality of life in aging companion dogs.” Gilad Fefer, Michael Z. Khan, Wojciech K. Panek, Beth Case, Margaret E. Gruen and Natasha J. Olby. Journal of Veterinary Internal Medicine, vol. 36, issue 5. Aug. 6, 2022. https://doi.org/10.1111/jvim.16510
  • “A Mutation in MTM1 Causes X-Linked Myotubular Myopathy in Boykin Spaniels.” Natasha J. Olby, Steven Friedenberg, Kathryn Meurs, Dylan DeProspero, Julien Guevar, Jeanie Lau, Oriana Yost, Ling T. Guo and G. Diane Shelton. Neuromuscular Disorders, vol. 30, issue 5. June 7, 2020. https://doi.org/10.1016/j.nmd.2020.02.021
  • “Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.” Tomoyuki Awano, Gary S. Johnson, Claire M. Wade, Martin L. Katz, Gayle C. Johnson, Jeremy F. Taylor, Michele Perloski, Tara Biagi, Izabella Baranowska, Sam Long, Philip A. March, Natasha J. Olby, G. Diane Shelton, Shahnawaz Khan, Dennis P. O’Brien, Kerstin Lindblad-Toh, and Joan R. Coates. Proceedings of the National Academy of Sciences, vol. 106, no. 8. Feb. 24, 2009. https://doi.org/10.1073/pnas.0812297106
  • “Brain Natriuretic Peptide Exerts Inflammation and Peripheral Itch in a Mouse Model of Atopic Dermatitis.” Joshua J. Wheeler, Nidha Williams, Junho Yu and Santosh K. Mishra. Journal of Investigative Dermatology, vol. 144, issue 3. Feb. 21, 2024. https://doi.org/10.1016/j.jid.2023.09.273

Immune

  • “The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis.” Barry A. Hedgespeth, Douglas B. Snider, Katie J. Bitting and Glenn Cruse. Frontiers in Immunology, vol. 14. Jan. 30, 2023. https://doi.org/10.3389/fimmu.2023.1006741
  • “Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst.” Drake W. Phelps, Anika I. Palekar, Haleigh E. Conley, Giuliano Ferrero, Jacob H. Driggers, Keith E. Linder, Seth W. Kullman, David M. Reif, M. Katie Sheats, Jamie C. DeWitt and Jeffrey A. Yoder. Journal of Immunotoxicology, vol. 20, issue 1. Feb. 14, 2023. https://doi.org/10.1080/1547691X.2023.2176953

Musculoskeletal

  • “Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing.” Yu-Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles and Shyni Varghese. Advanced Science, vol. 10, issue 36. Nov. 8, 2023. https://doi.org/10.1002/advs.202303567
  • “TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties.” Alix K. Berglund, Julie M. Long, James B. Robertson and Lauren V. Schnabel. Frontiers in Cell and Developmental Biology, vol. 9. Feb. 4, 2021. https://doi.org/10.3389/fcell.2021.628382
  • “Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the “core” of the problem through a one health approach.” Lauren V. Schnabel and Drew W. Koch. Journal of the American Veterinary Medical Association, vol. 261, issue 10. Aug. 29, 2023. https://doi.org/10.2460/javma.23.07.0388

Cardiovascular

  • “Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta).” Victor N. Rivas, Yu Ueda, Joshua A. Stern. Journal of Medical Primatology, vol. 52, issue 6. July 17, 2023. https://doi.org/10.1111/jmp.12662
  • “Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research.” Amanda E. Crofton, Samantha L. Kovacs and Joshua A. Stern. Cardiovascular Research, vol. 14, issue 5. October 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627371/

Respiratory

  • “Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury.” Durgesh Nandini Das, Bijesh Puthusseri, Venkadesaperumal Gopu, Venugopal Krishnan, Ashoka Kumar Bhagavath, Sudhir Bolla, Yogesh Saini, Gerald J. Criner, Nathaniel Marchetti, Hua Tang, Nagarjun V. Konduru, Liang Fan, and Sreerama Shetty. American Journal of Physiology – Lung Cellular and Molecular Physiology, vol. 325, issue 5. Nov. 2, 2023. https://doi.org/10.1152/ajplung.00178.2022
  • “Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice.” Ana Maria Gracioso Martins, Douglas B. Snider, Kristen D. Popowski, Karl G. Schuchard, Matias Tenorio, Sandip Akunuri, Junghyun Wee, Kara J. Peters, Anton Jansson, Rohan Shirwaiker, Ke Cheng, Donald O. Freytes and Glenn P. Cruse. Journal of Controlled Release, vol. 359. June 14, 2023. https://doi.org/10.1016/j.jconrel.2023.05.039

Gastrointestinal

  • “Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.” Matthew H. Foley, Morgan E. Walker, Allison K. Stewart, Sarah O’Flaherty, Emily C. Gentry, Shakshi Patel, Violet V. Beaty, Garrison Allen, Meichen Pan, Joshua B. Simpson, Caroline Perkins, Molly E. Vanhoy, Michael K. Dougherty, Sarah K. McGill, Ajay S. Gulati, Pieter C. Dorrestein, Erin S. Baker, Matthew R. Redinbo, Rodolphe Barrangou and Casey M. Theriot. Nature Microbiology, vol. 8. March 13, 2023. https://doi.org/10.1038/s41564-023-01337-7
  • “Developmental regulation of cellular metabolism is required for intestinal elongation and rotation.” Julia K. Grzymkowski, Yu-Chun Chiu, Dereje D. Jima, Brent H. Wyatt, Sudhish Jayachandran, Witney L. Stutts and Nanette M. Nascone-Yoder. Development, vol. 151, issue 4. Feb. 19, 2024. https://doi.org/10.1242/dev.202020